Hyperimmunity or immunodeficiency?

It’s 35yrs since this year since HIV entered our vocabulary and there’s still no sign of a vaccine or cure. But trickles of information persist in validating the dissident position:

Often, clinicians treating a patient with HIV will find that the patient has malfunctioning receptors and their body isn’t able to shut off their own immune systems, which can leave the body in a chronic proinflammatory state. If there is overactivation, this could lead to autoimmune disorders where the body attacks its own tissues. Conversely, if there is underactivation, the body is unable to fight off infections. “HIV patients are different because they can experience both,” said O’Connell.

Hyperimmunity locks with the Perth Group theory that there are too many antibodies to too many things, and it explains why people with multiple sclerosis – an autoimmune condition – can test ‘falsely’ positive.

Hypoimmunity is typically characterised by lack of inflammation (which is desired in people who receive donated organs), but lack of inflammation is not observed in HIV/AIDS. In fact, the presence of HIV-antibody-positivity confirms that the adaptive immune system is functioning; overfunctioning, most likely.

If one were to be infected with HIV but were not HIV-antibody-positive we could infer that either their innate immunity is well-primed or that their adaptive immunity has failed. In the latter case they should quickly succumb to AIDS because there is no fight against HIV. But untreated HIV/AIDS is meant to last years or decades.

If we’re talking about hyperimmunity, a human immunodeficiency virus is clearly a horrible joke. If it did exist it would probably balance hyperimmunity!

In other news, the Spanish edition of Joan Shenton’s Positively False is out tomorrow as Positivamente Falso. You can find it in paperback from Amazon, and in various places as an eBook.

I myself am working on a very short eBook on AIDS to serve as a primer. More info to come.